Ibogaine is a single isolated alkaloid that acts on the brain’s opioid, glutamate, dopamine, and serotonin transporter systems simultaneously — described in a 2026 Molecules scoping review as producing a neurobiological “reset” that no other plant-derived compound replicates. Ayahuasca is a brew that primarily activates 5-HT2A serotonin receptors, producing an immersive visionary and emotional experience over 4 to 6 hours. Ibogaine resets neural circuitry. Ayahuasca opens emotional and perceptual space.