Peyote lasts considerably longer. Effects typically begin two to four hours after ingestion and continue for 12 to 14 hours (Doesburg-van Kleffens et al., 2023). Ayahuasca onset arrives within 30 to 60 minutes, with peak effects running four to six hours (MDPI Pharmaceuticals, 2020). This difference in duration is structural. Peyote ceremonies are all-night events by design, while ayahuasca ceremonies are typically concluded before dawn.
