Some medicines are traditionally combined , rape alongside ayahuasca is common in Amazonian ceremony. Others carry serious risks. Ayahuasca’s MAOI alkaloids create severe serotonin syndrome risk when combined with SSRIs, MAOIs, or several other medications (Callaway and Grob, 1998). Combining iboga or ibogaine with any serotonergic compound, including ayahuasca, is considered highly dangerous. No combination of powerful psychedelic medicines should be undertaken without detailed consultation with a qualified practitioner.
