Not simultaneously. Ibogaine is a non-competitive serotonin transporter inhibitor (Coleman et al., 2019). Ayahuasca contains MAOIs and a direct serotonin agonist. Combining them creates compounded serotonergic risk that could be fatal. Sequential use — ibogaine first for detox, then ayahuasca months later for integration — is discussed in practitioner communities but has no clinical validation. Any sequential approach requires professional guidance and adequate integration time between experiences.