A few honest questions are more useful than any general answer. Do you have a personal or family history of psychosis, schizophrenia, or bipolar disorder with psychotic features? These are general contraindications for most psychedelic medicines. Are you currently taking SSRI or SNRI antidepressants? These require washout periods before ayahuasca and carry risks with other medicines. Do you have cardiovascular conditions? These are serious screening criteria for iboga and ibogaine in particular. Beyond medical considerations, readiness, intention, and access to proper preparation and integration support are the most consistent predictors of positive outcomes.
If you are working through medical considerations before a ceremony, the Ayahuasca Framework covers contraindications, medication interactions, and what to discuss with your doctor before you commit to anything.