Legal status varies significantly by medicine and jurisdiction. Ayahuasca is legally recognized in Colombia, Peru, and Brazil for ceremonial and religious use. Psilocybin has licensed supervised access in Oregon and Colorado. Peyote is Schedule I in the US with a specific exemption for Native American Church members. Rape is not scheduled in the US and is regulated as a tobacco product. Ibogaine has treatment clinic access in Mexico, Portugal, and several other countries outside US jurisdiction. For a detailed international legal breakdown, the ICEERS international legal overview is the most comprehensive resource available.