It depends on the medication. Some medications require a washout period before ayahuasca is safe. Serotonergic medications, specifically SSRIs, SNRIs, MAOIs, trazodone, triptans, and lithium, are contraindicated with ayahuasca’s MAOI compounds and require complete washout under medical supervision. If you are on any of these, the first step is a conversation with your prescribing doctor about whether stopping the medication is currently appropriate, and if so, the correct timeline. Do not stop a psychiatric medication without medical guidance. Bring the full list of your medications to your discovery call with MahaDevi (Malcolm and Thomas, 2018; ICEERS, 2019).
