Ayahuasca typically lasts 4 to 8 hours, with peak intensity in the middle 2 to 4 hours. Psilocybin mushrooms produce a 4 to 6 hour experience, with peak intensity in hours 1.5 to 3. Both have onset times of 20 to 60 minutes depending on stomach content and individual metabolism (Callahan et al., 2018). Ayahuasca ceremonies often run overnight; the longer duration is a practical reality of the format, not only of the substance.
