No. This is the most important safety question in this article. Ayahuasca’s beta-carboline alkaloids inhibit MAO-A, the same enzyme that MAOI antidepressants target. Combining them can produce dangerously elevated serotonergic activity, including risk of serotonin syndrome. SSRIs and SNRIs also interact dangerously with ayahuasca’s MAOI compounds (ICEERS, n.d.; White et al., 2024). If you take any medication affecting serotonin, consult a physician before any involvement with ayahuasca. Disclose all medications to any provider. This is not negotiable.
Understanding what ayahuasca actually does to your body chemistry is the first step in preparing responsibly. The free Ayahuasca Framework covers this in depth, including what to discuss with your doctor before you make any decisions.