No. This is the most important safety question in this article. Ayahuasca’s beta-carboline alkaloids inhibit MAO-A, the same enzyme that MAOI antidepressants target. Combining them can produce dangerously elevated serotonergic activity, including the risk of serotonin syndrome, a potentially serious medical emergency. SSRIs and SNRIs also interact dangerously with ayahuasca’s MAOI compounds (Callaway & Grob, 1998; Ruffell et al., 2020). If you take any medication affecting serotonin, consult a physician before any involvement with ayahuasca. Disclose all medications to any provider. This is not negotiable and not something to work around.
